Fertil Steril. 2013 May 4. Epub 2013 May 4. PMID: 23651625

Abstract Title: 

Serum bisphenol-A concentration and sex hormone levels in men.


OBJECTIVE: To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 290 men with or without BPA exposure in the workplace. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Serum sex hormone levels. RESULT(S): After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations. CONCLUSION(S): Exposure to a high BPA level may impact sex hormone levels in men.